추천 제품
Quality Level
분석
≥95% V basis
양식
powder
저장 조건
protect from light
색상
faintly yellow to dark yellow
solubility
H2O: 20 mg/mL, clear
저장 온도
−20°C
애플리케이션
bpV(pic) has been used in cell culture treatment to study the route of activation of multiple pathways required for HERV (human endogenous retroviruses) transcription.
생화학적/생리학적 작용
bpV(pic) contains a polar side chain, and specifically inhibits PTEN(phosphatase and tensin homolog) unlike its parent compound, which targets several other phosphatases too. Thus, making bpV(pic) more a prefered inhibitor. bpV(pic) is recognized as a potent activator of multiple sclerosis (an autoimmune disorder) related human endogenous retroviruses.
bpV(pic) is a bisperoxovanadium inhibitor of protein phosphotyrosine phosphatases with selectivity for phosphatase and tensin homolog (PTEN), a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(pic) are 31 nM for PTEN compared to 12.7 μM for PTPβ and 61 μM for PTP-1β. bpV(pic) can also act as an insulin mimetic and activate insulin receptor kinase (IRK).
기타 정보
Light Sensitive
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Compound signaling activates endogenous retroviruses by inducing enhancer and gene-neighborhood transcription.
bioRxiv, 284695 (2018)
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) as a molecular target in lung epithelial wound repair.
British Journal of Pharmacology, 152(8), 1172-1184 (2007)
Molecular brain, 14(1), 155-155 (2021-10-13)
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic effects of the phosphatase and tensin homolog (PTEN)
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