SML0889

bpV(phen)

≥95% V basis

• 동의어(들): Potassium bisperoxo(1,10-phenanthroline)oxovanadate (V) hydrate
• 실험식(Hill 표기법): KVO₅C₁₂H₈N₂ · xH₂O
• CAS Number: 42494-73-5
• Molecular Weight: 350.24 (anhydrous basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% V basis
• 양식: powder
• 저장 조건: protect from light
• 색상: faintly yellow to dark yellow
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K]
• InChI: 1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;;
• InChI key: MQPXOTNOFVCXDA-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

bpV(phen) (potassium bisperoxo(bipyridine)oxovanadate) shows protective effect against disease progression in leishmaniasis by mediating NO-dependent microbicidal action.

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC₅₀ values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation.

bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN.

기타 정보

Light Sensitive

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable