V8639
VO-OHpic trihydrate
≥98% (HPLC), solid
동의어(들):
(OC-6-45) Aqua (3-hydroxy-2-pyridinecarboxylato-kapaN1,kapaO2)[3-(hydroxy-kapaO)-2-pyridinecarboxylato(2-)-kapaO2]oxo-vanadate(1-), hydrogen, trihydrate
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C12H9N2O8V · H · 3H2O
CAS Number:
Molecular Weight:
415.20
UNSPSC 코드:
41121801
PubChem Substance ID:
NACRES:
NA.77
추천 제품
분석
≥98% (HPLC)
형태
solid
색상
gray
solubility
DMSO: >10 mg/mL
저장 온도
−20°C
SMILES string
O.O.O.O.Oc1cccnc1C(=O)O[VH]2(=O)OC(=O)c3cccnc3O2
InChI
1S/2C6H5NO3.4H2O.O.V.H/c2*8-4-2-1-3-7-5(4)6(9)10;;;;;;;/h2*1-3,8H,(H,9,10);4*1H2;;;/q;;;;;;;+3;/p-3
InChI key
QVBVJWFAUFEGMT-UHFFFAOYSA-K
일반 설명
VO-OHpic is a vanadium complex. VO-OHpic might act as a possible pro-senescence anti-cancer drug for treating cancers with reduced phosphatase and tensin homolog (PTEN) expression. It blocks cell viability, cell proliferation, colony formation and induced senescence-associated β-galactosidase activity in Hep3B cells.
애플리케이션
VO-OHpic trihydrate has been used in studying the role of phosphatase and tensin homolog (PTEN) in polycomb repressive complex 2 (PRC2)-mediated apoptosis. It also has been used as a PTEN inhibitor to study the neuroprotective effect of melatonin in amyloid beta (Aβ)-induced neurotoxicity via PTEN pathway.
생화학적/생리학적 작용
VO-OHpic trihydrate is a PTEN (phosphatase and tensin homologue deleted on chromosome 10) inhibitor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Ying-Zi Liu et al.
International journal of oncology, 45(1), 104-112 (2014-04-24)
Colon cancer is one of the most common malignancies and the treatments for colon cancer have been developed substantially in the last decades, but there is still a great clinical need to explore new treatment regimens due to the undesirable
Characterisation of the PTEN inhibitor VO-OHpic
Mak LH, et al.
Journal of Chemical Biology, 3(4), 157-163 (2010)
Pharmacological inhibition of polycomb repressive complex-2 activity induces apoptosis in human colon cancer stem cells
Benoit YD, et al.
Experimental Cell Research, 319(10), 1463-1470 (2013)
Melatonin protects against Abeta-induced neurotoxicity in primary neurons via miR-132/PTEN/AKT/FOXO3a pathway
Zhao Y, et al.
Biofactors (2018)
A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells
Augello G, et al.
Cell Cycle, 15(4), 573-583 (2016)
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