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Merck
모든 사진(1)

Key Documents

SML0684

Sigma-Aldrich

SF1670

≥98% (HPLC)

동의어(들):

N-(9,10-Dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide, N-(9,10-Dioxo-9,10-dihydro-phenanthren-2-yl)-2,2-dimethylpropionamide

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About This Item

실험식(Hill 표기법):
C19H17NO3
CAS Number:
Molecular Weight:
307.34
UNSPSC 코드:
12352200
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

색상

, light pink to red to very dark purple

solubility

DMSO: 10 mg/mL, clear

저장 온도

2-8°C

InChI

1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)

InChI key

VZQDDSYKVYARDW-UHFFFAOYSA-N

애플리케이션

SF1670 has been used:
  • To study the effect of microRNA-30a on PTEN (phosphatase and tensin homologue deleted on chromosome 10 ) expression regulation.
  • To study the formation of autophagosomes, induced by EGF (Epidermal growth factor) - dependent PTEN expression.
  • To study the role of PTEN in the regulation of autophagy induction in human normal endometrial stromal cells.

생화학적/생리학적 작용

PTEN prevents PI3-K(phosphoinositide 3-kinase)/Akt signaling pathway, which is very essential for neuronal regeneration. Therefore, inhibition of PTEN by SF1670 may support neuronal regeneration.
SF1670 is a selective PTEN (phosphatase and tensin homolog) inhibitor with an IC50 of 2 micromolar. PTEN inhibition by SF1670 was shown to increase neutrophil activity (polarization, phagocytosis, oxidative burst, and recruitment to site of infection), thereby enhancing the inflammatory response and bacteria-killing capacity of neutopenic mice.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Aberrant PTEN expression in response to progesterone reduces endometriotic stromal cell apoptosis.
Choi J, et al.
Reproduction (Cambridge, England), 153(1), 11-21 (2017)
Bioinformatics prediction of miR-30a targets and its inhibition of cell proliferation of osteosarcoma by up-regulating the expression of PTEN.
Zhong B, et al.
BMC Medical Genomics, 10(1), 64-64 (2017)
Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells.
Ryu J W, et al.
Oncotarget, 8(3), 4181-4181 (2017)
PTEN inhibition to facilitate intrinsic regenerative outgrowth of adult peripheral axons.
Christie K J, et al.
The Journal of Neuroscience, 30(27), 9306-9315 (2010)
Stefanie Kälin et al.
Cell metabolism, 26(3), 475-492 (2017-09-07)
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3

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