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S7067

Sigma-Aldrich

SB 202190

≥98% (HPLC), powder, p38 MAP kinase inhibitor

동의어(들):

4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole

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모든 사진(3)

About This Item

실험식(Hill 표기법):
C20H14FN3O
CAS Number:
152121-30-7
Molecular Weight:
331.34
MDL number:
MFCD00941964
UNSPSC 코드:
12352200
PubChem Substance ID:
24278272
NACRES:
NA.77

product name

SB 202190, ≥98% (HPLC)

Quality Level

100

분석

≥98% (HPLC)

형태

powder

색상

faintly yellow, to beige

solubility

DMSO: 10 mg/mL, clear

주관자

GlaxoSmithKline

저장 온도

2-8°C

SMILES string

Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4

InChI

1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24)

InChI key

QHKYPYXTTXKZST-UHFFFAOYSA-N

유전자 정보

human ... MAPK14(1432)

일반 설명

SB202190 aids in enhancing the self-renewal ability of neural stem cells fromNPC1-deficient mice.

애플리케이션

SB 202190 has been used:
  • to investigate the role of p38mitogen-activated protein kinase (MAPK) signaling in establishment of reovirus infection
  • as a p38α inhibitor in in vivo studies to study its impact on the development or progression of adenocarcinoma in the colon mucosa tissues of APC Min/+ mice.
  • as a component of basic BC medium to culture basal progenitor cells.
  • as a component of normal endometrium and endometrial tumor media for organoid culture.
SB 202190 was used to inhibit p38 activation in MCF7 cells5, mouse macrophages6 and HepG2 cells.7

생화학적/생리학적 작용

SB 202190 is a highly selective, potent and cell permeable inhibitor of p38 MAP kinase. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms.

특징 및 장점

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

법적 정보

Sold for research purposes under agreement from Glaxo­Smith­Kline

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

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C J Chang et al.
European journal of clinical investigation, 36(8), 588-596 (2006-08-09)
The molecular mechanisms underlying the mitogenic effect of ferulic acid (FA), an active compound derived from Angelica sinensis, have never been elucidated. It was the aim of this study to investigate the proliferative effect of FA on human breast cancer
Carissa C James et al.
Molecular biology of the cell (2018-02-23)
Epithelial-mesenchymal transition (EMT) is activated during development, wound healing, and pathologies including fibrosis and cancer metastasis. Hallmarks of EMT are remodeling of intercellular junctions and adhesion proteins, including gap junctions. The GJA1 mRNA transcript encoding the gap junction protein connexin43
Lívia das Graças Amaral Avelar et al.
Frontiers in immunology, 10, 21-21 (2019-02-09)
Eukaryotic protein kinases (ePKs) are good medical targets for drug development in different biological systems. ePKs participate in many cellular processes, including the p38 MAPK regulation of homeostasis upon oxidative stress. We propose to assess the role of Smp38 MAPK
Edward Thorp et al.
The Journal of biological chemistry, 286(38), 33335-33344 (2011-08-11)
Mer tyrosine kinase (MerTK) is an integral membrane protein that is preferentially expressed by phagocytic cells, where it promotes efferocytosis and inhibits inflammatory signaling. Proteolytic cleavage of MerTK at an unidentified site leads to shedding of its soluble ectodomain (soluble
Natalia Calvo et al.
Journal of molecular endocrinology, 59(1), 13-27 (2017-04-08)
Parathyroid hormone-related peptide (PTHrP) is associated with several human cancers such as colon carcinoma. This disease is a complex multistep process that involves enhanced cell cycle progression and migration. Recently we obtained evidence that in the human colorectal adenocarcinoma Caco2
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