SML0800

Rimonabant hydrochloride

≥98% (HPLC), powder, cannabinoid type-I receptor antagonist

• 동의어(들): 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide hydrochloride, SR-141716, SR-141716A, SR141716, SR141716A
• 실험식(Hill 표기법): C₂₂H₂₁Cl₃N₄O · HCl
• CAS Number: 158681-13-1
• Molecular Weight: 500.25
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825601
• NACRES: NA.77

속성

• product name: Rimonabant hydrochloride, ≥98% (HPLC)
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NN4CCCCC4)=O.Cl
• InChI: 1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H
• InChI key: REOYOKXLUFHOBV-UHFFFAOYSA-N
• 유전자 정보: human ... CNR1(1268)

설명

애플리케이션

Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:

• to study its effects on protein synthesis in C2C12 myotubes
• to analyze its effects on human astroglia
• in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

생화학적/생리학적 작용

Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.

Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.

특징 및 장점

This compound is featured on the Cannabinoid Receptors and Cannabinoid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H319
• 예방조치 성명서: P264 - P270 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable