SML0448

URB937

≥95% (HPLC)

• 동의어(들): Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester
• 실험식(Hill 표기법): C₂₀H₂₂N₂O₄
• CAS Number: 1357160-72-5
• Molecular Weight: 354.40
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥95% (HPLC)
• 양식: powder (1:1 ratio of product to ethanol)
• 색상: white to beige
• solubility: DMSO: 15 mg/mL, clear
• 저장 온도: −20°C
• InChI: 1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
• InChI key: CMEQHOXCIGFZNJ-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED₅₀ for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable