SML0113

Brequinar sodium salt hydrate

≥97% (HPLC)

• 동의어(들): 6-Fluoro-2-(2′-fluoro[1,1′-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium hydrate, Biphenquinate sodium hydrate, DuP 785 hydrate, NSC 368390 hydrate
• 실험식(Hill 표기법): C₂₃H₁₄F₂NO₂·Na · xH₂O
• CAS Number: 96187-53-0
• Molecular Weight: 397.35 (anhydrous basis)
• MDL number: MFCD21363375
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825165
• NACRES: NA.77

속성

• 분석: ≥97% (HPLC)
• 형태: powder
• 색상: off-white to brown
• solubility: DMSO: ≥5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O.[Na+].Cc1c(nc2ccc(F)cc2c1C([O-])=O)-c3ccc(cc3)-c4ccccc4F
• InChI: 1S/C23H15F2NO2.Na.H2O/c1-13-21(23(27)28)18-12-16(24)10-11-20(18)26-22(13)15-8-6-14(7-9-15)17-4-2-3-5-19(17)25;;/h2-12H,1H3,(H,27,28);;1H2/q;+1;/p-1
• InChI key: IZXTTXFXRQGHKO-UHFFFAOYSA-M

설명

애플리케이션

Brequinar sodium salt hydrate has been used as a dihydroorotate dehydrogenase (DHODH) inhibitor:

• in drug response assays
• to induce depletion of cellular pyrimidine pools
• in cell proliferation assays

Brequinar sodium salt hydrate may be used in cell signaling studies.

생화학적/생리학적 작용

Brequinar exhibits anti-neoplastic activity against refractory solid tumors in human and mouse models. Continuous treatment is required for depletion of pyrimidine pools in the cancer cells and tumor inhibition.

Brequinar inhibits dihydroorotate dehydrogenase (DHODH), the fourth enzyme in the de novo pyrimidine biosynthesis pathway, preventing the synthesis of DNA and RNA. Brequinar has recently been found to have antiviral activity against a broad spectrum of viruses including flaviviruses (dengue virus, West Nile virus, yellow fever virus, and Powassan virus) and also a plus-strand RNA alphavirus (Western equine encephalitis virus) and a negative-strand RNA rhabdovirus (vesicular stomatitis virus).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable