추천 제품
생물학적 소스
rabbit
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 67 kDa
종 반응성
mouse, rat, human
농도
~1 mg/mL
기술
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAP3K7(6885)
일반 설명
Anti-TAK1 antibody detects endogenous levels of total TAK1 protein.
The TAK1 (Transforming growth factor β activated kinase 1) gene is mapped to human chromosome 6q15. It encodes for a mitogen-activated protein kinase 7 containing serine-threonine/tyrosine-protein kinase catalytic domain and a coiled-coil domain at the C-terminal.
면역원
The antiserum was produced against synthesized peptide derived from human TAK1.
Immunogen Range: 161-210
Immunogen Range: 161-210
생화학적/생리학적 작용
TAK1 (Transforming growth factor β (TGF-β) activated kinase 1) is activated by TGF-β and other inflammatory stimuli such as chemical and physical agents causing stress, cytokines, and microorganism moieties. TAK1 participates in mitogen-activated protein kinase (MAPK)-p38 signaling pathway. TAK1 is involved in the regulation of osteogenesis. TAK1 is important for productive autophagy.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Wade EM
American Journal of Human Genetics, 99(2), 392-406 (2016)
TAK1 Regulates the Nrf2 Antioxidant System Through Modulating p62/SQSTM1.
Hashimoto K
Antioxidants & Redox Signaling, 25(17), 953-964 (2016)
Heterozygous Mutations in MAP3K7, Encoding TGF-?-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.
Le Goff C
American Journal of Human Genetics, 99(2), 407-413 (2016)
TAK1 is involved in the autophagy process in retinal pigment epithelial cells.
Green YA
Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 94(2), 188-196 (2016)
Martina Kluth et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 26(7), 975-983 (2013-02-02)
6q12-22 is the second most commonly deleted genomic region in prostate cancer. Mapping studies have described a minimally deleted area at 6q15, containing MAP3K7/TAK1, which was recently shown to have tumor suppressive properties. To determine prevalence and clinical significance of
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