06-1334

Anti-phospho-TAB1 (Thr431) Antibody

from rabbit, purified by affinity chromatography

• 동의어(들): TGF-beta activated kinase 1/MAP3K7 binding protein 1, TAK1-binding protein 1, transforming growth factor beta-activated kinase-binding protein 1, mitogen-activated protein kinase kinase kinase 7 interacting protein 1, Mitogen-activated protein kinase kin
• UNSPSC 코드: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 정제법: affinity chromatography
• 종 반응성: rat, human, horse, mouse
• 종 반응성(상동성에 의해 예측): equine (based on 100% sequence homology), ox (based on 100% sequence homology)
• 기술: western blot: suitable
• NCBI 수납 번호: NP_006107
• UniProt 수납 번호: Q15750
• 배송 상태: wet ice
• 타겟 번역 후 변형: phosphorylation (pThr431)
• 유전자 정보: human ... TAB1(10454)

설명

일반 설명

TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.

특이성

This antibody recognizes TAB1 phosphorylated at Thr431.

면역원

Epitope: Phosphorylated Thr431

KLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431.

애플리케이션

Research Category
Inflammation & Immunology

Research Sub Category
Immunoglobulins & Immunology

This Anti-phospho-TAB1 (Thr431) Antibody is validated for use in WB for the detection of phospho-TAB1 (Thr431).

품질

Evaluated by Western Blot in L6 cell lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate.

표적 설명

~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates.

물리적 형태

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

저장 및 안정성

Stable for 1 year at 2-8°C from date of receipt.

분석 메모

Control
L6 cell lysate

기타 정보

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable