SAB4504268

Anti-phospho-TAK1 (pThr¹⁸⁴) antibody produced in rabbit

affinity isolated antibody

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen 67 kDa
• 종 반응성: human, rat, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:1000; western blot: 1:500-1:1000
• NCBI 수납 번호: O43318
• UniProt 수납 번호: O43318
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pThr184)
• 유전자 정보: human ... MAP3K7(6885)

설명

일반 설명

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) is encoded by MAP3K7. TAK1 is a 606-residue protein, that contains a serine-threonine/tyrosine-protein kinase catalytic domain and a C-terminal coiled-coil domain. It is a member of the mitogen-activated protein kinase kinase kinase family (MAP3K). This gene is mapped to human chromosome 6q15.

면역원

The antiserum was produced against synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184.

Immunogen Range: 161-210

생화학적/생리학적 작용

Transforming growth factor β (TGF-β)-activated kinase 1 (TAK1) participates in the mitogen-activated protein kinase (MAPK)-p38 signaling pathway. This gene also participates in the autophagy process in retinal pigment epithelial cells. Mutations in MAP3K7 result in cardiospondylocarpofacial syndrome.

특징 및 장점

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물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable