S8559

Sinefungin

95% (HPLC), powder, methylation of bases in DNA & RNA inhibitor

• 동의어(들): 5′-Deoxy-5′-(1,4-diamino-4-carboxybutyl)adenosine, A-9145, Adenosylornithine, Antibiotic 32232RP
• 실험식(Hill 표기법): C₁₅H₂₃N₇O₅
• CAS Number: 58944-73-3
• Molecular Weight: 381.39
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899800
• NACRES: NA.77

속성

• product name: Sinefungin, 95% (HPLC), powder
• Quality Level: 200
• 분석: 95% (HPLC)
• 형태: powder
• 색상: white to yellow
• solubility: H₂O: complete 20 mg/ml, clear, colorless to light yellow; H₂O: soluble
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1
• InChI key: LMXOHSDXUQEUSF-YECHIGJVSA-N

설명

일반 설명

Chemical structure: nucleoside

애플리케이션

Sinefungin was used to inhibit global methyltransferases in breast cancer cell line, MCF7² and Jurkat cells.³ It was used as S-adenosylmethionine analogue in equilibrium FRET experiments.⁴

생화학적/생리학적 작용

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.

Sinefungin blocks the methylation of bases in DNA and RNA, such as 5-methylcytosine or N⁶-methyladenosine, suggesting a role in gene expression. In addition, sinefugin is involved in physiological processes such as aging and carcinogenesis.
Methylation inhibition by sinefugin is often accompanied by an altered rate of cytosine deamination that is coupled to transition mutation in the DNA. Sinefugin inhibits Epstein-Barr viral activity and this inhibition is related to the change in DNA methylation and gene expression. It can cause a rate change in several restriction DNA endonuclease activities, including Mme I, which is not connected to the inhibition of the methytransferase activity.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves