Q3251

Quinacrine dihydrochloride

≥90% (TLC), powder, MAO-A/B inhibitor

• 동의어(들): 6-Chloro-9-(4-diethylamino-1-methylbutylamino)-2-methoxyacridine dihydrochloride, Atebrin dihydrochloride, Mepacrine dihydrochloride
• 실험식(Hill 표기법): C₂₃H₃₀ClN₃O · 2HCl
• CAS Number: 69-05-6
• Molecular Weight: 472.88
• Beilstein: 4834013
• EC Number: 200-700-8
• MDL number: MFCD00012659
• UNSPSC 코드: 12352101
• PubChem Substance ID: 24278192
• NACRES: NA.77

속성

• 제품명: Quinacrine dihydrochloride, ≥90%
• 생물학적 소스: synthetic
• Quality Level: 100
• 분석: ≥90%
• 양식: powder
• mp: 257 °C
• solubility: H₂O: soluble, clear to hazy
• 주관자: Bayer
• SMILES string: Cl[H].Cl[H].CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13
• InChI: 1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H
• InChI key: UDKVBVICMUEIKS-UHFFFAOYSA-N
• 유전자 정보: human ... MAOA(4128) , MAOB(4129)

설명

일반 설명

Quinacrine is an acridine derivative and a potent antimalarial agent.

애플리케이션

Quinacrine dihydrochloride has been used:

• in its uptake and accumulation studies in mouse lung slices using fluorescence microscope
• in the staining of ATP vesicles in mesenchymal stem cells (MSCs)
• in uptake-release assay for characterization of dense granule functionality of platelets

생화학적/생리학적 작용

Quinacrine has anthelmintic functionality and used in the female sterilization. It is used to treat systemic lupus erythematosus and rheumatic diseases. Apart from malaria, Quinacrine is effective for treating giardia and tapeworm infections. It inhibits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in addition to monoamine oxidase inhibition.

Non-selective MAO-A/B inhibitor.

특징 및 장점

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

저장 및 안정성

Stock solutions are stable for up to 60 h at 20°C.

기타 정보

This product is not assigned an expiration date or recommended retest date.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves