Q2763

Quinalizarin

≥95% (HPLC), powder, plasmodium falciparum casein kinase 2α (PfCK2α) inhibitor

• 동의어(들): 1,2,5,8-Tetrahydroxy-9,10-anthraquinone, 1,2,5,8-Tetrahydroxyanthraquinone, Alizarin Bordeaux BD, Alizarinbordeaux, Alizarine Bordeaux, Alizarine Bordeaux B, C.I. 58500, C.I. Mordant Violet 26, Khinalizarin, NSC 144046, NSC 4896, PHF 016
• 실험식(Hill 표기법): C₁₄H₈O₆
• CAS Number: 81-61-8
• Molecular Weight: 272.21
• 색상 지수 번호: 58500
• Beilstein: 1889617
• EC Number: 201-366-6
• MDL number: MFCD00001205
• UNSPSC 코드: 12171500
• PubChem Substance ID: 329823863
• NACRES: NA.77

속성

• product name: Quinalizarin, ≥95% (HPLC)
• Quality Level: 100
• 분석: ≥95% (HPLC)
• 형태: powder
• 색상: red
• mp: ≥300 °C
• 저장 온도: room temp
• SMILES string: Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O
• InChI: 1S/C14H8O6/c15-6-3-4-7(16)11-10(6)12(18)5-1-2-8(17)13(19)9(5)14(11)20/h1-4,15-17,19H
• InChI key: VBHKTXLEJZIDJF-UHFFFAOYSA-N

설명

애플리케이션

Quinalizarin has been used:

• as a casein kinase II (CKII) inhibitor to study its effect on CKII-mediated phosphorylation of importin α on subcellular scaling in sperm chromosomes and egg extract
• as a CKII inhibitor to study its ability to block parasite multiplication in a [3H]-hypoxanthine incorporation assay
• to study its effect on colorectal cancer (CRC) cell cycle arrest, cell apoptosis, and reactive oxygen species (ROS) generation in SW480 and HCT-116 cell lines

생화학적/생리학적 작용

Quinalizarin is a potent (IC50 = 110 nM), ATP-competitive, and highly selective (IC50 >1μM against CK1 and 72 other kinases) casein Kinase II (CK2) inhibitor.

Studies show that quinalizarin can prevent the in vitro activity of recombinant Plasmodium falciparum casein kinase 2α (PfCK2α) catalytic subunit with an IC50 of 2μM.

안전성 정보

• 픽토그램: GHS07,GHS09
• 신호어: Warning
• 유해 및 위험 성명서: H302,H410
• 예방조치 성명서: P264 - P270 - P273 - P301 + P312 - P391 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable