추천 제품
생물학적 소스
synthetic (organic)
분석
≥97%
양식
powder
색상
white to off-white
mp
145-148 °C
solubility
DMSO: 50 mg/mL
SMILES string
O=[As]c1ccccc1
InChI
1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H
InChI key
BQVCCPGCDUSGOE-UHFFFAOYSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Phenylarsine oxide (PhAsO4) is a bifunctional SH group chemical. It is hydrophobic in nature.
애플리케이션
Phenylarsine oxide has been used to infuse animals with a nigrostriatal transection, to determine whether peroxovanadium (pVa) would synergize with brain-derived neurotrophic factor (BDNF).
생화학적/생리학적 작용
Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.
Phenylarsine oxide (PAO) can reduce the motility and sustainability of Setaria cervi. It has the ability to stimulate cyclosporin A-sensitive transition in the presence of EGTA (ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid). It acts as a stimulator of mitochondrial ion fluxes.
특징 및 장점
This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
이미 열람한 고객
Inhibition of setaria cervi protein tyrosine phosphatases by phenylarsine oxide: A proteomic and biochemical study
Singh N, et al.
Acta Tropica, 159, 20-28 (2016)
Phenylarsine oxide induces the cyclosporin A-sensitive membrane permeability transition in rat liver mitochondria
Lenartowicz E, et al.
Journal of Bioenergetics and Biomembranes, 23(4), 679-688 (1991)
Tyrosine phosphatase inhibition enhances neurotrophin potency and rescues nigrostriatal neurons in adult rats
Lu X, et al.
Experimental neurology, 178(2), 259-267 (2002)
M Wachtel et al.
Journal of cell science, 112 ( Pt 23), 4347-4356 (1999-11-24)
Regulation of epithelial and endothelial permeability is essential for proper function of compartmentalized organisms, and tyrosine phosphorylation plays an important role in this process. We analyzed the impact of protein tyrosine phosphatase (PTP) inhibition on the structure of endothelial junctional
Erik H Christen et al.
Protein expression and purification, 66(2), 158-164 (2009-03-28)
Inducer-dependent prokaryotic transcriptional repressor proteins that originally evolved to orchestrate the transcriptome with intracellular and extracellular metabolite pools, have become universal tools in synthetic biology, drug discovery, diagnostics and functional genomics. Production of the repressor proteins is often limited due
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.