H8627

Hydroxyurea

98% (elemental analysis), powder, RNR inhibitor

• 동의어(들): Hydroxycarbamide
• Linear Formula: NH₂CONHOH
• CAS Number: 127-07-1
• Molecular Weight: 76.05
• Beilstein: 1741548
• EC Number: 204-821-7
• MDL number: MFCD00007943
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278474
• NACRES: NA.77

속성

• 제품명: Hydroxyurea, 98%, powder
• 분석: 98%
• 양식: powder
• 색상: white
• solubility: H₂O: 50 mg/mL
• 저장 온도: 2-8°C
• SMILES string: NC(=O)NO
• InChI: 1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
• InChI key: VSNHCAURESNICA-UHFFFAOYSA-N
• 유전자 정보: human ... CA1(759) , CA2(760) , CYP1A2(1544) , RRM1(6240) , RRM2(6241) , RRM2B(50484)

설명

일반 설명

Hydroxyurea is a hydroxylated analog of urea. It is beneficial in increasing fetal hemoglobin (HbF) levels, which in turn reduces the frequency of severe crises and the need for blood transfusions in sickle cell anemia patients. Hydroxyurea exhibits cell-cycle specificity for the S phase, leading to cell arrest at G1 to S. This non-alkylating S phase-specific myelosuppressive agent has a mechanism of action that is not specific to platelets.

애플리케이션

Hydroxyurea has been used:

• for cell cycle synchronization in MCF-7 human breast carcinoma cells, Schizosaccharomyces pombe, primary root of seedling
• as a drug for treating the parasite Leishmania mexicana in cell viability and cell cycle assay
• as an inhibitor in the cell adhesion and motility assay in Caki control and CD9 knockdown cells

생화학적/생리학적 작용

Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.

특징 및 장점

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안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340,H361
• 예방조치 성명서: P201 - P308 + P313
• Hazard Classifications: Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges