M7945

Mephetyl tetrazole

≥98% (HPLC), oil

• 동의어(들): 1-[2-(4-Methoxyphenyl)ethyl]-5-(1-p-tolylcyclopropyl)-1H-tetrazole
• 실험식(Hill 표기법): C₂₀H₂₂N₄O
• CAS Number: 916923-10-9
• Molecular Weight: 334.41
• MDL number: MFCD11045297
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818044
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: oil
• 색상: pale yellow
• solubility: DMSO: >5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: COc1ccc(CCn2nnnc2C3(CC3)c4ccc(C)cc4)cc1
• InChI: 1S/C20H22N4O/c1-15-3-7-17(8-4-15)20(12-13-20)19-21-22-23-24(19)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3
• InChI key: VREPWWBWXVLSEF-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC₅₀ = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)