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일반 설명
5-(Ethylthio)-1H-tetrazole (ETT) is an efficient activator, that activates nucleoside phosphoramidites towards condensation with a nucleoside to form dinucleoside phosphates during oligonucleotide synthesis.
애플리케이션
- Solid-Phase Synthesis of Symmetrical Dinucleoside Phosphodiesters: Explores the efficiency of 5-(Ethylthio)-1H-tetrazole in the solid-phase synthesis of dinucleoside phosphodiesters, underlining its significance in the streamlined production of biologically relevant molecules (Ahmadibeni et al., 2007).
- Synthesis, Deprotection, Analysis, and Purification of RNA and Ribozymes: Utilizes 5-(Ethylthio)-1H-tetrazole in the synthesis and processing of RNA and ribozymes, highlighting its critical role in molecular biology and genetic engineering research (Wincott et al., 1995).
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B - STOT SE 3
표적 기관
Respiratory system
보충제 위험성
Storage Class Code
4.1A - Other explosive hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
An efficient method for the isolation and purification of oligoribonucleotides.
Sproat B, et al.
Nucleosides, nucleotides & nucleic acids, 14(1-2), 255-273 (1995)
Gregor S Cremosnik et al.
Angewandte Chemie (International ed. in English), 53(1), 286-289 (2013-11-14)
P-Amidites can be used in iterative couplings to selectively give mixed P(III) -P(V) anhydrides. These intermediates can be oxidized followed by a rapid removal of the two terminal fluorenylmethyl groups. An iterative synthesis (coupling, oxidation, deprotection) of nucleoside oligophosphates can
Benzimidazolium Triflate as an Efficient Promoter for Nucleotide Synthesis via the Phosphoramidite Method.
Yoshihiro Hayakawa et al.
The Journal of organic chemistry, 61(23), 7996-7997 (1996-11-15)
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