M2199

PMEG hydrate

≥98% (HPLC)

• 동의어(들): 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate
• 실험식(Hill 표기법): C₈H₁₂N₅O₅P · xH₂O
• CAS Number: 1255517-79-3
• Molecular Weight: 289.19 (anhydrous basis)
• MDL number: MFCD19443863
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329817932
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: desiccated
• 색상: white to off-white
• solubility: DMSO: ≥5 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O.NC1=Nc2c(ncn2CCOCP(O)(O)=O)C(=O)N1
• InChI: 1S/C8H12N5O5P.H2O/c9-8-11-6-5(7(14)12-8)10-3-13(6)1-2-18-4-19(15,16)17;/h3H,1-2,4H2,(H2,15,16,17)(H3,9,11,12,14);1H2
• InChI key: BDVQXHFCXJXVND-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H300
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 2 Oral
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3