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Merck
모든 사진(1)

문서

PHR1254

Supelco

Acyclovir

Pharmaceutical Secondary Standard; Certified Reference Material

동의어(들):

Acycloguanosine, 9-[(2-Hydroxyethoxy)methyl]guanine, Acyclovir

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About This Item

실험식(Hill 표기법):
C8H11N5O3
CAS Number:
Molecular Weight:
225.20
EC Number:
MDL number:
UNSPSC 코드:
41116107
PubChem Substance ID:
NACRES:
NA.24

Grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 438
traceable to Ph. Eur. A0220000
traceable to USP 1012065

API family

acyclovir

CofA

current certificate can be downloaded

기술

HPLC: suitable
gas chromatography (GC): suitable

응용 분야

pharmaceutical (small molecule)

형식

neat

저장 온도

2-30°C

SMILES string

NC1=Nc2c(ncn2COCCO)C(=O)N1

InChI

1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)

InChI key

MKUXAQIIEYXACX-UHFFFAOYSA-N

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일반 설명

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Acyclovir is an acyclic guanosine derivative effective in the treatment of skin infections caused by herpes simplex virus.

애플리케이션

Acyclovir may be used as a pharmaceutical reference standard for the determination of the analyte in plasma, serum samples and bulk drug/formulations by various chromatography techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

분석 메모

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

기타 정보

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

각주

To see an example of a Certificate of Analysis for this material enter LRAC2956 in the slot below. This is an example certificate only and may not be the lot that you receive.

추천 제품

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

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문서 라이브러리 방문

Simple spectrophotometric determination of acyclovir in bulk drug and formulations
Basavaiah K and Prameela HC
Il Farmaco (Societa Chimica Italiana : 1989), 57(6), 443-449 (2002)
Determination of acyclovir in human serum by high-performance liquid chromatography using liquid--liquid extraction and its application in pharmacokinetic studies
Bahrami Gh, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 327-331 (2005)
Determination of acyclovir in human plasma by high-performance liquid chromatography
Boulieu R, et al
Journal of Chromatography. B, Biomedical Sciences and Applications, 693(1), 233-236 (1997)
Adalbert Krawczyk et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(17), 6760-6765 (2013-04-10)
Despite the availability of antiviral chemotherapy, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) infections remain a severe global health problem. Of particular concern is the growing incidence of drug resistance in immunocompromised patients, which stresses the urgency
Daniel S Owers et al.
The Cochrane database of systematic reviews, 2(2), CD005133-CD005133 (2013-03-02)
Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in solid organ transplant recipients. Pre-emptive treatment of patients with CMV viraemia using antiviral agents has been suggested as an alternative to routine prophylaxis to prevent CMV disease. This is

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