M0321

MDM2, GST-tagged human

recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥75% (SDS-PAGE)

• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 설명: contains an N-terminal GST tag
• 분석: ≥75% (SDS-PAGE)
• 양식: buffered aqueous glycerol solution
• 분자량: ~84 kDa
• UniProt 수납 번호: Q00987
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... MDM2(4193)

설명

일반 설명

Murine double minute 2 (MDM2) encoding gene is localized at 12q15 in the human chromosome. It is a multidomain nuclear phosphoprotein. It possesses really interesting new gene (RING) finger domain and its function and structural integrity is required for the action of MDM2. It also has central acidic domain.

생화학적/생리학적 작용

MDM2 is a negative regulator of the p53 tumor suppressor.

Mdm2 functions as an E3 ubiquitin ligase and an inhibitor of p53 transcriptional activation.

Murine double minute 2 (MDM2) is a chief regulator of the p53 tumor suppressor protein. It is a multifunctional oncoprotein that contributes to both p53-dependent and -independent roles in oncogenesis. MDM2 has various p53-independent functions that contribute to its activity as an oncogene.

Overexpression of Murine double minute 2 (MDM2) is observed in various cancer like lung, gastric, colorectal, hepatocellular, breast, endometrial, and prostate. A common single nucleotide polymorphism is observed at 309 amino acid (from T to G) increases the susceptibility to cancer.

물리적 형태

Solution in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF and 25% glycerol.

제조 메모

Supplied as a truncated version (202-end) with an N-terminal GST tag

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)