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Merck
모든 사진(3)

문서

L2774

Sigma-Aldrich

Lincomycin hydrochloride

suitable for cell culture, BioReagent

동의어(들):

Lincocin hydrochloride, Methyl 6,8-dideoxy-6-(1-methyl-4-propyl-2-pyrrolidinecarboxamido)-1-thio-D-erythro-α-D-galactooctopyranoside hydrochloride

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About This Item

실험식(Hill 표기법):
C18H34N2O6S · HCl
CAS Number:
Molecular Weight:
443.00
Beilstein:
4171650
EC Number:
MDL number:
UNSPSC 코드:
12352207
PubChem Substance ID:
NACRES:
NA.76

product name

Lincomycin hydrochloride, BioReagent, suitable for cell culture

제품 라인

BioReagent

효능

800-900 units per mg

기술

cell culture | mammalian: suitable

색상

white to yellow-white

solubility

H2O: 4 mL, clear, colorless to faintly yellow (200 mg + 4 mL H2O)

항생제 활성 스펙트럼

Gram-positive bacteria

동작 모드

protein synthesis | interferes

저장 온도

2-8°C

SMILES string

Cl.CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O

InChI

1S/C18H34N2O6S.ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1

InChI key

POUMFISTNHIPTI-BOMBIWCESA-N

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일반 설명

Chemical structure: macrolide

애플리케이션

Lincomycin hydrochloride is an antibiotic used to study the inhibition of protein synthesis, bacterial antibiotic resistance and protein and surfactant binding. It is produced by Streptomyces lincolnensis var. lincolnensis, and has been used in the treatment of Staphylococcal, Streptococcal, and Bacterioides fragilis infections.

생화학적/생리학적 작용

Mode of action: Lincomycin inhibits bacterial protein synthesis by forming cross-links within the peptidyl transferase loop region of the 23S rRNA.†

Antimicrobial spectrum: Lincomycin hydrochloride is effective against gram-positive bacteria.

제조 메모

This product is soluble in water at 50 mg/mL, yielding a clear, colorless solution.

픽토그램

Exclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves


시험 성적서(COA)

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Yongjian Qiu et al.
Nature communications, 10(1), 140-140 (2019-01-13)
Ambient temperature sensing by phytochrome B (PHYB) in Arabidopsis is thought to operate mainly at night. Here we show that PHYB plays an equally critical role in temperature sensing during the daytime. In daytime thermosensing, PHYB signals primarily through the
Ulrich Schreiber et al.
Photosynthesis research, 114(3), 165-177 (2013-02-15)
A new type of multi-color PAM chlorophyll fluorometer (Schreiber et al. 2012) was applied for measurements of photodamage to photosystem II (PS II) in optically thin suspensions of Chlorella (200 μg Chl l(-1)) in the presence of 1 mM lincomycin.
Isaac M Hagenbuch et al.
Water research, 46(16), 5028-5036 (2012-07-24)
The role that antibiotics and other "emerging contaminants" play in shaping environmental microbial communities is of growing interest. The use of the prokaryotic metabolic inhibitors tylosin (T), lincomycin (L), and ciprofloxacin (C) in livestock and humans is both global and
Steven L Berry et al.
Veterinary journal (London, England : 1997), 193(3), 654-658 (2012-08-16)
The objective of this study was to observe the dynamics of clinical cure and recurrence of the lesions of bovine digital dermatitis for 11 months after treatment with topical lincomycin HCl. The study was a clinical follow-up of 39 active
PanGyi Kim et al.
Chemosphere, 89(1), 10-18 (2012-05-09)
Chronic toxicity of acetaminophen and lincomycin were evaluated using freshwater organisms including two crustaceans (Daphnia magna and Moina macrocopa) and a fish (Oryzias latipes). H295R, a human adrenal cell was also used to understand the effects on steroidogenesis. In 21

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