추천 제품
생물학적 소스
human
Quality Level
재조합
expressed in E. coli
분석
≥95%
양식
buffered aqueous solution
분자량
19 kDa
포장
pkg of 100K units
기술
cell culture | mammalian: suitable
불순물
endotoxin, tested
색상
colorless
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... IFNA2(3440)
애플리케이션
Interferon-αA/D human has been used:
- for identification of coronavirus replicase inhibitors
- in combination with ACH-806 [1-(4-pentyloxy-3-trifluoromethylphenyl)-3-(pyridine-3-carbonyl)thiourea] to study the effect on hepatitis C virus (HCV) replication
- in combination with vitamin D to check reduction in HCV protein production in cell culture
생화학적/생리학적 작용
Interferon-αA/D (Bg/II), also known as Universal Type I Interferon, is an α interferon hybrid that crosses the species barrier. The Bg/II denotes the restriction enzyme site from which this hybrid is constructed from recombinant human interferons αA and αD. Interferon-αA/D has been proven to be active on many mammalian cells. It can substitute for human, monkey, mouse, bovine, rat, cat, dog, rabbit, sheep, goat, horse, pig or hamster type I interferon (α, β, ω and τ). Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes), and ruminant embryos (τ subtypes). This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
This cytokine has anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities.
물리적 형태
Solution in phosphate buffered saline containing 0.1% bovine serum albumin
분석 메모
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to NIH international standard reference for human interferonαA.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves
이미 열람한 고객
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The Journal of general virology, 85(Pt 6), 1717-1725 (2004-05-29)
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Antimicrobial agents and chemotherapy, 52(5), 1862-1864 (2008-03-12)
Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside
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