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Merck
모든 사진(1)

Key Documents

SRP4596

Sigma-Aldrich

IFN-alpha 1 human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)

동의어(들):

IFN-α 1, IFNA1, Interferon-α

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About This Item

MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥95% (HPLC)
≥95% (SDS-PAGE)

형태

lyophilized

효능

1x10^8 units/mg

분자량

~19.3 kDa

포장

pkg of 100 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

endotoxin, tested

NCBI 수납 번호

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... IFNA1(3439)

일반 설명

IFN-α1 (interferon α 1) is a type 1 interferon. Human IFN-a1 is a 19.3kDa protein containing 166 amino acid residues. IFN-α1 belongs to the type I interferon (IFN) family and is present in leukocytes. The IFN-α1 gene is mapped to human chromosome 9p21.3.

애플리케이션

IFN-alpha 1 human has been used:
  • to treat Vero and breast cancer (MDA-MB-231) cells in interferon assay before viral infection
  • as a ligand to vaccinia virus B18R protein in analytical size exclusion chromatography
  • to treat chikungunya infected human embryonic kidney cell line (HEK293T) to test its effect on Signal transducer and activator of transcription 1 (STAT1) phosphorylation
  • as recombinant interferon to treat lung fibroblast cell line (IMR90) to monitor histone chaperone (HIRA) response

생화학적/생리학적 작용

IFN-α1 (interferon α 1) is a lymphoid factor that possesses potent anti-viral activity. IFN-α1 interacts with IFNAR1 (interferon α receptor 1) and IFNAR2. The interaction activates JAK1 (janus-activated kinase 1) and tyrosine kinase 2. These events phosphorylate and activate STAT1 and STAT2 (signal transducer and activator of transcription proteins), leading to the upregulation of interferon-stimulated genes some of which encode antiviral proteins. IFN-alpha 1 (IFN-α1) mediates apoptosis in specific tissues. It may be useful in treating laryngeal carcinoma. The interaction of microRNA, miR-181b with IFN-α1, is regarded as a risk factor in systemic lupus erythematosus.

물리적 형태

Lyophilized without any additives.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1 mg/mL. This solution can then be diluted into other aqueous buffers.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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Glioblastomas (GBMs) are deadly tumors of the central nervous system. Most GBM exhibit homozygous deletions of the CDKN2A and CDKN2B tumor suppressors at 9p21.3, although loss of CDKN2A/B alone is insufficient to drive gliomagenesis. MIR31HG, which encodes microRNA-31 (miR-31), is
Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.
Zoon KC, et al.
The Journal of Biological Chemistry, 267, 15210-15216 (1992)
Marina Juraleviciute et al.
Cancer medicine, 10(8), 2840-2854 (2021-03-19)
MX2 is an interferon inducible gene that is mostly known for its antiviral activity. We have previously demonstrated that MX2 is also associated with the tumorigenesis process in melanoma. However, it remains unknown which molecular mechanisms are regulated by MX2
Saisai Wang et al.
Journal of cellular and molecular medicine, 19(10), 2432-2440 (2015-06-30)
Src homology phosphotyrosyl phosphatase 2 (Shp-2) is a ubiquitously expressed protein that is involved in a variety of cellular processes, including antiviral interferon signalling pathways. In this study, we investigated the role of Shp-2 in the host cell interactions of
Xing Liu et al.
Journal of virology, 93(2) (2018-11-09)
Oncolytic herpes simplex virus 1 (HSV-1), devoid of the γ134.5 gene, exerts antitumor activities. However, the oncolytic effects differ, ranging from pronounced to little responses. Although viral and host factors are involved, much remains to be deciphered. Here we report

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