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Merck
모든 사진(2)

주요 문서

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H128

Sigma-Aldrich

(R)(−)-α-Methylhistamine dihydrochloride

solid, ≥98% (HPLC)

동의어(들):

(R)(−)-α-Methyl-1H-imidazole-4-ethanamine dihydrochloride

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C6H11N3 · 2HCl
CAS Number:
75614-89-0
Molecular Weight:
198.09
MDL number:
MFCD00083176
UNSPSC 코드:
12352116
PubChem Substance ID:
24277778
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

solid

광학 활성

[α]22/D −4°, c = 0.8 in H2O(lit.)

저장 조건

desiccated

색상

white to off-white

solubility

H2O: soluble

SMILES string

Cl.Cl.C[C@@H](N)Cc1c[nH]cn1

InChI

1S/C6H11N3.2ClH/c1-5(7)2-6-3-8-4-9-6;;/h3-5H,2,7H2,1H3,(H,8,9);2*1H/t5-;;/m1../s1

InChI key

IZHCNQFUWDFPCW-ZJIMSODOSA-N

유전자 정보

human ... HRH3(11255)

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애플리케이션

(R)(−)-α-Methylhistamine dihydrochloride has been used as an agonist for the histamine H3 cell lines. It has also been used in the antagonist assay for the histamine H3 cell lines.

생화학적/생리학적 작용

(R)(−)-α-Methylhistamine dihydrochloride is a potent, selective H3 histamine receptor agonist which crosses the blood-brain barrier. It can inhibit histamine synthesis and release.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
036M4622V
043M4608V
070M4615
098K4603
038K4606

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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Sigma-Aldrich

H7125

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Sigma-Aldrich

C3618

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Sigma-Aldrich

H7250

Histamine dihydrochloride

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Gerhard, et al.
Archives of Pharmacal Research, 313, 709-709 (1980)
J M Arrang et al.
Nature, 327(6118), 117-123 (1987-05-14)
New drugs selective for histamine H3-receptors can be used to establish that these receptors are involved in the feedback control of histamine synthesis and release, and to demonstrate their distribution in the brain and peripheral tissues. These drugs provide new
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R Oishi et al.
Journal of neurochemistry, 52(5), 1388-1392 (1989-05-01)
To study the feedback control by histamine (HA) H3-receptors on the synthesis and release of HA at nerve endings in the brain, the effects of a potent and selective H3-agonist, (R)-alpha-methylhistamine, and an H3-antagonist, thioperamide, on the pargyline-induced accumulation of

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