H0915

Hydroxychloroquine sulfate

≥98% (HPLC), powder

• 동의어(들): Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• 실험식(Hill 표기법): C₁₈H₂₆ClN₃O · H₂SO₄
• CAS Number: 747-36-4
• Molecular Weight: 433.95
• EC Number: 212-019-3
• MDL number: MFCD00078203
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329815141
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: powder
• 저장 조건: protect from light
• 색상: white to off-white
• solubility: H₂O: >20 mg/mL
• SMILES string: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• InChI key: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• 유전자 정보: human ... TLR7(51284) , TLR9(54106)

설명

애플리케이션

Hydroxychloroquine sulfate has been used:

• as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
• to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
• to inhibit lysosome fusion with the autophagosome

생화학적/생리학적 작용

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 - H315 - H319
• 예방조치 성명서: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves