G2536

Ganciclovir

≥99% (HPLC), powder

• 동의어(들): 2-Amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one, 9-(1,3-Dihydroxy-2-propoxymethyl)guanine, DHPG
• 실험식(Hill 표기법): C₉H₁₃N₅O₄
• CAS Number: 82410-32-0
• Molecular Weight: 255.23
• MDL number: MFCD00870588
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278453
• NACRES: NA.77

속성

• Quality Level: 300
• 분석: ≥99% (HPLC)
• 형태: powder
• 색상: white
• solubility: 0.1 M HCl: 10 mg/mL
• ε (흡광계수): 12.0 at 256 nm at 1 mM
• 항생제 활성 스펙트럼: viruses
• 동작 모드: DNA synthesis | interferes
• 주관자: Roche
• 저장 온도: 2-8°C
• SMILES string: NC1=Nc2c(ncn2COC(CO)CO)C(=O)N1
• InChI: 1S/C9H13N5O4/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16/h3,5,15-16H,1-2,4H2,(H3,10,12,13,17)
• InChI key: IRSCQMHQWWYFCW-UHFFFAOYSA-N

설명

일반 설명

Chemical structure: nucleoside

애플리케이션

Ganciclovir is used in molecular biology for selection against random recombination events when homologous recombination of a gene of interest is required.

생화학적/생리학적 작용

Ganciclovir is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research.
Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. The cell cycle is irreversibly arrested at the G2-M checkpoint. Gap junction involvement in the ganciclovir bystander effect has been studied. Ganciclovir has been used to study loss of telomeres and to evaluate sensitivity of viruses to antiviral treatments.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

제조 메모

Ganciclovir is soluble in 0.1 M HCl (10 mg/ml), DMSO (5 mg/ml), water (2 mg/ml), hot methanol, and ethanol (<1 mg/ml).
This product should be stored desiccated at 2-8 °C. Under these conditions the product is stable for 3 years.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H340 - H361fd
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 1B - Repr. 2
• Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges