F8257

Flunarizine dihydrochloride

≥98% (TLC)

• 동의어(들): 1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
• 실험식(Hill 표기법): C₂₆H₂₆F₂N₂ · 2HCl
• CAS Number: 30484-77-6
• Molecular Weight: 477.42
• Beilstein: 4284243
• EC Number: 250-216-6
• MDL number: MFCD00058198
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277835
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 주관자: Johnson & Johnson
• 저장 온도: 2-8°C
• SMILES string: Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
• InChI: 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
• InChI key: RXKMOPXNWTYEHI-RDRKJGRWSA-N

설명

일반 설명

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

애플리케이션

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

생화학적/생리학적 작용

Blocks T-type Ca²⁺/Na⁺ channels.

Blocks T-type Ca²⁺/Na⁺ channels; inhibits K⁺-induced catecholamine release from chromaffin cells

특징 및 장점

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves