B7880

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt

≥97% (HPLC), powder

• 동의어(들): 8-Br-cAMP
• 실험식(Hill 표기법): C₁₀H₁₀BrN₅NaO₆P
• CAS Number: 76939-46-3
• Molecular Weight: 430.08
• Beilstein: 7739743
• MDL number: MFCD00005844
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24278020
• NACRES: NA.77

속성

• 분석: ≥97% (HPLC)
• 형태: powder
• 색상: off-white
• solubility: H₂O: 100 mg/mL
• 저장 온도: −20°C
• SMILES string: [Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Br)nc12
• InChI: 1S/C10H11BrN5O6P.Na/c11-10-15-4-7(12)13-2-14-8(4)16(10)9-5(17)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,17H,1H2,(H,18,19)(H2,12,13,14);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChI key: DMRMZQATXPQOTP-GWTDSMLYSA-M

설명

일반 설명

8-Bromoadenosine 3′:5′-cyclic monophosphate is a brominated cyclic mononucleotide.

애플리케이션

8-Bromoadenosine 3′,5′-cyclic monophosphate sodium salt has been used:

• to study its effect on fas and caspase-3 mRNA expression and on P4 production in bovine mid luteal cell culture
• used to treat choriocarcinoma BeWo cell line and study its effect on cell viability, apoptosis and morphological changes in the nuclei
• in superfusion medium for head kidneys stimulation

생화학적/생리학적 작용

Cell-permeable cAMP analog having greater resistance to hydrolysis by phosphodiesterases than cAMP. Activates protein kinase A, inhibits growth, decreases proliferation, increases differentiation, and induces apoptosis of cultured cells.

특징 및 장점

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기타 정보

Membrane-permeable cAMP analog.

주의사항

Sensitive to light and moisture.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)