A9501

Adenosine 3′,5′-cyclic monophosphate

≥98.5% (HPLC), powder, PKA activator

• 동의어(들): 3′,5′-Cyclic AMP, Adenosine 3′,5′-cyclophosphate, cAMP
• 실험식(Hill 표기법): C₁₀H₁₂N₅O₆P
• CAS Number: 60-92-4
• Molecular Weight: 329.21
• Beilstein: 52645
• EC Number: 200-492-9
• MDL number: MFCD00005845
• UNSPSC 코드: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24278245
• NACRES: NA.77

속성

• 제품명: Adenosine 3′,5′-cyclic monophosphate, ≥98.5% (HPLC), powder
• 분석: ≥98.5% (HPLC)
• 양식: powder
• 색상: white
• mp: 260 °C (dec.) (lit.)
• solubility: H₂O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
• 저장 온도: −20°C
• SMILES string: Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
• InChI: 1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• InChI key: IVOMOUWHDPKRLL-KQYNXXCUSA-N
• 유전자 정보: human ... OPRK1(4986)

설명

애플리케이션

Adenosine 3′,5′-cyclic monophosphate has been used:

• as cell culture medium supplement in embryonic spinal neurons
• as a component of ringer solution for perfusion studies
• to induce neuroendocrine differentiation in human lung cancer cell lines

생화학적/생리학적 작용

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). The cAMP/PKA signaling pathway inhibits cell proliferation, induces differentiation and leads to apoptosis.

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

특징 및 장점

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)