G7504

Guanosine 3′,5′-cyclic monophosphate

≥98% (HPLC), powder, intracellular mediator

• 동의어(들): cGMP, cyclic GMP
• 실험식(Hill 표기법): C₁₀H₁₂N₅O₇P
• CAS Number: 7665-99-8
• Molecular Weight: 345.21
• EC Number: 231-641-6
• MDL number: MFCD00070129
• UNSPSC 코드: 41106305
• PubChem Substance ID: 24895309
• NACRES: NA.77

속성

• 제품명: Guanosine 3′,5′-cyclic monophosphate, ≥98% (HPLC), powder
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white
• solubility: 0.2 M NaHCO₃: 50 mg/mL
• 저장 온도: −20°C
• SMILES string: NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1
• InChI: 1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)
• InChI key: ZOOGRGPOEVQQDX-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

특징 및 장점

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves