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F6300

Sigma-Aldrich

Flumazenil

>99% (HPLC), solid, benzodiazepine receptor antagonist

동의어(들):

Ro 15-1788, Ro15-1788

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모든 사진(3)

About This Item

실험식(Hill 표기법):
C15H14FN3O3
CAS Number:
78755-81-4
Molecular Weight:
303.29
MDL number:
MFCD00242764
UNSPSC 코드:
12352200
PubChem Substance ID:
24278437
NACRES:
NA.77

product name

Flumazenil, >99% (HPLC), solid

분석

>99% (HPLC)

형태

solid

색상

white

주관자

Roche

저장 온도

2-8°C

SMILES string

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(F)ccc-23

InChI

1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

OFBIFZUFASYYRE-UHFFFAOYSA-N

유전자 정보

human ... BZRAP1(9256) , GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)
rat ... Gabra2(29706) , Gabrg1(140674)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Flumazenil reverses sedative and hypnotic effects of benzodiazepines. It is used to increase acquisition, enhance retention and treat amnesia in mice.

생화학적/생리학적 작용

Highly specific benzodiazepine receptor antagonist.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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이미 열람한 고객

Slide 1 of 6

1 of 6

Omeprazole solid

Sigma-Aldrich

O104

Omeprazole

Phaclofen solid

Sigma-Aldrich

P118

Phaclofen

Galantamine Hydrobromide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1623

Galantamine Hydrobromide

(+)-Bicuculline ≥97.0% (TLC)

Sigma-Aldrich

14340

(+)-Bicuculline

PK 11195

Sigma-Aldrich

C0424

PK 11195

Luzindole ≥90%

Sigma-Aldrich

L2407

Luzindole

A A Weinbroum et al.
Drug safety, 17(3), 181-196 (1997-11-05)
The worldwide expansion in the use of benzodiazepines has led to their frequent, and often inappropriate, use and to increase in their involvement in self-induced poisoning and iatrogenic overdosing. Flumazenil is a specific and competitive antagonist at the central benzodiazepine
A A Weinbroum et al.
European journal of anaesthesiology, 18(12), 789-797 (2001-12-12)
Midazolam may occasionally precipitate hostility and violence instead of tranquility. We characterized these episodes, their rate of occurrence, the potential paradoxical responders and possible predisposing circumstances among patients undergoing lower body surgery under spinal or epidural anaesthesia and midazolam sedation.
Pasquale Molinaro et al.
Molecular pharmacology, 83(1), 142-156 (2012-10-16)
Previous studies have demonstrated that the knockdown or knockout of the three Na(+)/Ca(2+) exchanger (NCX) isoforms, NCX1, NCX2, and NCX3, worsens ischemic brain damage. This suggests that the activation of these antiporters exerts a neuroprotective action against stroke damage. However
Sabine M J Welten et al.
Circulation research, 115(8), 696-708 (2014-08-03)
Effective neovascularization is crucial for recovery after cardiovascular events. Because microRNAs regulate expression of up to several hundred target genes, we set out to identify microRNAs that target genes in all pathways of the multifactorial neovascularization process. Using www.targetscan.org, we
Donna L Seger
Journal of toxicology. Clinical toxicology, 42(2), 209-216 (2004-06-25)
Flumazenil is frequently administered to the poisoned patient. Seizures may be precipitated and resedation may occur in patients who awakened following flumazenil administration. Seizures may increase morbidity and mortality of the overdose. Benefit:Risk ratio of administering flumazenil should be determined
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