P6500
Pentylenetetrazole
≥99% (GC), powder, CNS stimulant
동의어(들):
α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole
로그인조직 및 계약 가격 보기
모든 사진(3)
About This Item
실험식(Hill 표기법):
C6H10N4
CAS Number:
Molecular Weight:
138.17
EC Number:
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
제품명
Pentylenetetrazole,
양식
powder
bp
194 °C/12 mmHg (lit.)
mp
59-61 °C (lit.)
저장 온도
−20°C
SMILES string
C1CCc2nnnn2CC1
InChI
1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2
InChI key
CWRVKFFCRWGWCS-UHFFFAOYSA-N
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일반 설명
Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier.
애플리케이션
Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.
생화학적/생리학적 작용
Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
표적 기관
Respiratory system
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
이미 열람한 고객
Effects of bee products on pentylenetetrazole-induced seizures in the rat
Zarraga-Galindo N, et al.
Proceedings of the Western Pharmacology Society, 54, 33-40 (2011)
Central nervous system uptake kinetics of pentylenetetrazol in the developing rat
Haberer LJ and Pollack GM
Biopharmaceutics & Drug Disposition, 12(1), 59-71 (1991)
Tatiana Afrikanova et al.
PloS one, 8(1), e54166-e54166 (2013-01-24)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of
Rufi Tambe et al.
Pharmaceutical biology, 55(1), 264-268 (2016-12-09)
Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically
Shehla Akbar et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 962-971 (2016-10-21)
Diabetic neuropathy is the most prevalent, persistent and debilitating complication of diabetes mellitus often coupled with vulvodynia that may present as an isolated symptom or as a part of constellation of other neuropathic abnormalities. Flavonoids have selective affinity for GABA
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