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Merck
모든 사진(2)

주요 문서

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F2552

Sigma-Aldrich

Formestane

solid

동의어(들):

4-Hydroxyandrost-4-ene-3,17-dione, CGP-32349

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C19H26O3
CAS Number:
566-48-3
Molecular Weight:
302.41
MDL number:
MFCD00057814
UNSPSC 코드:
12352204
PubChem Substance ID:
24894827
NACRES:
NA.25

생물학적 소스

synthetic (organic)

Quality Level

100

분석

≥98% (HPLC)

양식

solid

기술

HPLC: suitable
gas chromatography (GC): suitable

solubility

chloroform: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

응용 분야

forensics and toxicology
veterinary

저장 온도

2-8°C

SMILES string

C[C@]12CC[C@H]3[C@@H](CCC4=C(O)C(=O)CC[C@]34C)[C@@H]1CCC2=O

InChI

1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1

InChI key

OSVMTWJCGUFAOD-KZQROQTASA-N

유전자 정보

human ... CYP19A1(1588)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

생화학적/생리학적 작용

Aromatase inhibitor used as an anti-cancer agent against estrogen-dependent tumors.

픽토그램

Health hazard
GHS08

신호어

Danger

유해 및 위험 성명서

H360

Hazard Classifications

Repr. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

개인 보호 장비

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
MKCN7345
MKCF5599
MKCC3385
MKBX1177V
SLBF2564V

적합한 버전을 찾을 수 없으신가요?

특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Ichiro Sakata et al.
The Journal of endocrinology, 190(3), 749-757 (2006-09-28)
Ghrelin, an endogenous ligand for the GH secretagogue receptor, is predominantly produced in the stomach. Little is known about the regulation mechanism of gastric ghrelin. Here, we report that estrogen synthesized in the stomach induces rat gastric ghrelin gene expression
P E Lønning
Breast cancer research and treatment, 49 Suppl 1, S45-S52 (1998-10-31)
Steroidal aromatase inhibitors like formestane and exemestane are useful drugs for endocrine treatment of postmenopausal breast cancer. In addition, these drugs should be considered valuable probes to explore the biology of breast cancer with particular emphasis on possible relations between
Aaron T Wright et al.
Journal of the American Chemical Society, 131(30), 10692-10700 (2009-07-09)
Cytochrome P450 (P450) enzymes regulate a variety of endogenous signaling molecules and play central roles in the metabolism of xenobiotics and drugs. We recently showed that an aryl alkyne serves as an effective activity-based probe for profiling mouse liver microsomal
Sanjay K Sharma et al.
Bioorganic & medicinal chemistry letters, 18(20), 5563-5566 (2008-09-26)
Synthesis of 4-amino-4,6-androstadiene-3,17-dione 7, an analog of formestane used in breast cancer therapy as an aromatase inhibitor, from 4-acetoxy-4-androstene-3,17-dione 2 is described. This is the first report of a 4-amino diene (4,6) system in this series of molecules. The new
P E Lønning et al.
The Journal of steroid biochemistry and molecular biology, 77(1), 39-47 (2001-05-19)
Formestane (Lentaron(R), 4-hydroxyandrostenedione) is a steroidal aromatase inhibitor used for treatment of advanced breast cancer. Clinically, it is administered as a depot form once fortnightly by intramuscular (i.m.) injection. To investigate the pharmacokinetics, bioavailability and metabolism of the drug, seven
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