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Merck
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주요 문서

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E1896

Sigma-Aldrich

Etazolate hydrochloride

solid

동의어(들):

1-Ethyl-4-[(1-methylethylidene)hydrazino]1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester hydrochloride, SQ 20009

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About This Item

실험식(Hill 표기법):
C14H18N5O2 · HCl
CAS Number:
35838-58-5
Molecular Weight:
324.79
MDL number:
MFCD00209848
UNSPSC 코드:
41106305
PubChem Substance ID:
24278825

분석

≥98% (TLC)

형태

solid

색상

white

mp

193-194  °C

solubility

H2O: >20 mg/mL (Solutions should be freshly prepared.)

저장 온도

room temp

SMILES string

Cl.CCOC(=O)c1cnc2n(CC)ncc2c1N\N=C(\C)C

InChI

1S/C14H19N5O2.ClH/c1-5-19-13-10(8-16-19)12(18-17-9(3)4)11(7-15-13)14(20)21-6-2;/h7-8H,5-6H2,1-4H3,(H,15,18);1H

InChI key

GQJUGJHJUZSJLZ-UHFFFAOYSA-N

유전자 정보

human ... GABRB3(2562) , PRKAR1A(5573) , PRKAR1AP(5574) , PRKAR1B(5575) , PRKAR2A(5576) , PRKAR2B(5577)

생화학적/생리학적 작용

Selective inhibitor of cAMP-specific phosphodiesterase.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

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문서 라이브러리 방문

Distinction of benzodiazepine receptor agonists and inverse agonists by binding studies in vitro.
M Karobath et al.
Advances in biochemical psychopharmacology, 38, 37-45 (1983-01-01)
A K Mehta et al.
Journal of neurochemistry, 49(5), 1491-1497 (1987-11-01)
The interaction of [3H]flunitrazepam and its modulation by various drugs was studied in intact primary cultured spinal cord neurons. In the intact cells, the [3H]-flunitrazepam binding was rapid and saturable. The benzodiazepine binding sites exhibited high affinity and saturability, with
G Maksay et al.
Journal of neurochemistry, 44(2), 480-486 (1985-02-01)
The dissociation of [35S]t-butylbicyclophosphorothionate ([35S]TBPT) from binding sites on membranes from rat cerebral cortex, after addition of saturating concentrations of convulsant and depressant drugs, was studied. The addition of unlabeled TBPT, picrotoxinin, or pentamethylenetetrazol resulted in dissociation patterns that were
Ankur Jindal et al.
European journal of pharmacology, 689(1-3), 125-131 (2012-06-16)
Etazolate, a pyrazolopyridine class derivative is selective inhibitor of type 4 phosphodiesterase (PDE4), an enzyme catalyzes the hydrolysis of cyclic nucleotide viz. cAMP & regulates cAMP signal transduction. Enhancing cAMP signal transduction by inhibition of PDE4 is known to be
E H Wong et al.
European journal of pharmacology, 102(2), 205-212 (1984-07-13)
Barbiturates and the related depressant drugs, etazolate and etomidate, inhibited both the binding of [3H]bicuculline methochloride (BMC) to gamma-aminobutyric acid (GABA) receptor sites and the binding of [3H] beta-carboline-3-carboxylic acid methyl ester (beta CCM) to benzodiazepine receptor sites in mammalian
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