D8174

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α

≥98% (HPLC), solution, thromboxane A2 agonist

• 동의어(들): U-46619, U46619
• 실험식(Hill 표기법): C₂₁H₃₄O₄
• CAS Number: 56985-40-1
• Molecular Weight: 350.49
• Beilstein: 4267334
• MDL number: MFCD00135238
• UNSPSC 코드: 12352211
• PubChem Substance ID: 24894197
• NACRES: NA.77

속성

• 제품명: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F_2α, solution, 10 mg/mL in methyl acetate
• 양식: solution
• Quality Level: 200
• 농도: 10 mg/mL in methyl acetate
• 배송 상태: dry ice
• 저장 온도: −20°C
• SMILES string: CCCCC[C@H](O)\C=C\[C@H]1C2CC(CO2)[C@@H]1C\C=C/CCCC(O)=O
• InChI: 1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16?,17-,18-,19+,20?/m0/s1
• InChI key: LQANGKSBLPMBTJ-REGKDVDGSA-N

설명

일반 설명

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is an endoperoxide/thromboxane analog.

애플리케이션

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α has been used:

• to induce aortic smooth muscle (SM) contraction in mice deficient in myosin light chain 9 (Myl9) gene
• to induce contraction as part of vascular reactivity experiments using mice aorta
• as a thromboxane/prostaglandin agonist to study the effect of dithiothreitol (DTT) on mice arterial vessel viability

생화학적/생리학적 작용

9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α is a thromboxane A2 agonist. It is useful in in vitro experiments to induce shape change, aggregation, secretion, phosphoinositide hydrolysis, and protein phosphorylation in platelets. It also causes an elevation in the cytosolic Ca⁺⁺ levels slightly affecting the cyclic adenosine monophosphate (cAMP) formation. It acts as a potent stimulator of vascular cell adhesion molecule-1 (VCAM-1), which mediates leukocyte adhesion to the endothelium.

특징 및 장점

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS02,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H225,H319,H336
• 예방조치 성명서: P210 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• 표적 기관: Central nervous system
• 보충제 위험성: EUH066
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point (°F): 14.0 °F
• Flash Point (°C): -10 °C
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter