C9911

(S)-(+)-Camptothecin

≥90% (HPLC), powder, DNA topoisomerase I inhibitor

• 동의어(들): (S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
• 실험식(Hill 표기법): C₂₀H₁₆N₂O₄
• CAS Number: 7689-03-4
• Molecular Weight: 348.35
• Beilstein: 631069
• MDL number: MFCD00081076
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278352
• NACRES: NA.77

속성

• 제품명: (S)-(+)-Camptothecin, ≥90% (HPLC), powder
• 분석: ≥90% (HPLC)
• 양식: powder
• mp: 260 °C (dec.) (lit.)
• solubility: chloroform/methanol (4:1): 5 mg/mL
• 항생제 활성 스펙트럼: neoplastics
• 동작 모드: DNA synthesis | interferes; enzyme | inhibits
• 저장 온도: 2-8°C
• SMILES string: CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
• InChI: 1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
• InChI key: VSJKWCGYPAHWDS-FQEVSTJZSA-N
• 유전자 정보: human ... TOP1(7150) ; mouse ... Prkca(18750) ; rat ... Sstr2(54305)

설명

생화학적/생리학적 작용

(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.

특징 및 장점

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기타 정보

20S isomer

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H340
• 예방조치 성명서: P202 - P264 - P280 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Muta. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges