TOP1
topoisomerase (DNA) I
Synonyms:
TOPI
Species:
Human TOP1 (7150), Mouse Top1 (21969), Rat Top1 (64550), fruit fly Top1 (32458), domestic cat TOP1 (101093174), dog TOP1 (477229), chicken TOP1 (396004), Zebrafish top1 (327179), domestic guinea pig Top1 (100716716), naked mole-rat Top1 (101704241) ...More
UniProtKB ID:
Gene ID:
- Human(7150) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]
- Mouse(21969) topoisomerase (DNA) I
- Rat(64550) topoisomerase (DNA) I
- fruit fly(32458) Topoisomerase 1
- domestic cat(101093174) topoisomerase (DNA) I
- dog(477229) topoisomerase (DNA) I
- chicken(396004) topoisomerase (DNA) I
- Zebrafish(327179) topoisomerase (DNA) I
- domestic guinea pig(100716716) topoisomerase (DNA) I
- naked mole-rat(101704241) topoisomerase (DNA) I
- cow(534799) topoisomerase (DNA) I
- sheep(101103086) topoisomerase (DNA) I
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-TOP1 antibody produced in mouse, clone 1A1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Monoclonal Anti-Topoisomerase I antibody produced in mouse, clone Mab1, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
microarray
western blot
western blot
Anti-TOP1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-DNA topoisomerase I (TOP1) Antibody, clone 3D4W6, Rabbit Monoclonal, ,
Species Reactivity
human, rat
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Topoisomerase I-DNA Covalent Complexes Antibody, clone 1.1A, clone 1.1A, from mouse,
Species Reactivity
human, mouse
Application
ELISA
dot blot
flow cytometry
immunocytochemistry
dot blot
flow cytometry
immunocytochemistry
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
Topo I (197-651) (core domain) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human
Topo I (N1-197) (NTD) human, recombinant, expressed in insect cells, ≥85% (SDS-PAGE),
Species
human
Topo I (Y723F) (mt Y723F) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human
Topo I (C651-765) (C terminal domain) human, recombinant, expressed in insect cells, ≥80% (SDS-PAGE),
Species
human