C9758

L-Canavanine sulfate salt

≥99% (TLC), powder

• 동의어(들): L-α-Amino-γ-(guanidinooxy)butyric acid sulfate salt
• 실험식(Hill 표기법): C₅H₁₂N₄O₃ · H₂SO₄
• CAS Number: 2219-31-0
• Molecular Weight: 274.25
• Beilstein: 6121291
• EC Number: 218-728-4
• MDL number: MFCD00012618
• UNSPSC 코드: 12352209
• PubChem Substance ID: 24278349
• NACRES: NA.32

속성

• 생물학적 소스: plant seeds (Jack bean )
• 분석: ≥99% (TLC)
• 형태: powder
• 색상: white
• mp: 160-165 °C (dec.)
• solubility: H₂O: 100 mg/mL
• 저장 온도: 2-8°C
• SMILES string: OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
• InChI: 1S/C5H12N4O3.H2O4S/c6-3(4(10)11)1-2-12-9-5(7)8;1-5(2,3)4/h3H,1-2,6H2,(H,10,11)(H4,7,8,9);(H2,1,2,3,4)/t3-;/m0./s1
• InChI key: MVIPJKVMOKFIEV-DFWYDOINSA-N
• 유전자 정보: human ... NOS2(4843)

설명

일반 설명

Canavanine is a homolog of arginine and a non-protein amino acid. It is present in plants like alfalfa, cloves, beans onions and sprouts. Canavanine is synthesized from L-canavaninosuccinic acid and the biosynthetic pathway was first elucidated in jack bean plant.

애플리케이션

Canavanine sulfate salt has been used:

• as a translation inhibitor in yeast translation studies
• as a component of synthetic complete (SC) drop-out medium for screening yeast
• for screening Saccharomyces cerevisiae in canavanine mutation frequency assay

생화학적/생리학적 작용

Canavanine is a naturally occurring L-amino acid that competes and interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). It acts as a substrate for arginyl tRNA and is incorporated during protein synthesis leading to aberrant canavanyl proteins. Supplementation with canavanine worsens the alfalfa induced Systemic lupus erythematosus (SLE) like syndrome and its incorporation with endosome and proteasome disrupts the antigen processing.

Naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity with this L-amino acid. It is a selective inhibitor of inducible nitric oxide synthase (iNOS).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves