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Merck
모든 사진(1)

문서

C8977

Sigma-Aldrich

Monoclonal Anti-CREB antibody produced in rabbit

clone 48H2, purified immunoglobulin, buffered aqueous glycerol solution

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모든 사진(1)

About This Item

MDL number:
MFCD01092316
UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

rabbit

Quality Level

200

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

48H2, monoclonal

형태

buffered aqueous glycerol solution

분자량

antigen 43 kDa

종 반응성

rat, human, monkey, mouse

기술

ChIP: 1:50
flow cytometry: 1:400
immunocytochemistry: 1:800
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:6,400
immunohistochemistry (frozen sections): 1:6,400
immunoprecipitation (IP): 1:250
indirect immunofluorescence: 1:800
western blot: 1:1,000 using extracts from SK-N-MC cells treated with forskolin or FGF

동형

IgG

UniProt 수납 번호

P16220

배송 상태

wet ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... CREB1(1385)
mouse ... Creb1(12912)
rat ... Creb1(81646)

특이성

Detects endogenous levels of total CREB protein.

면역원

Recombinant protein specific to amino terminus of human CREB.

물리적 형태

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/mL bovine serum albumin, and < 0.02% sodium azide with 50% glycerol.

법적 정보

Rabbit monoclonals produced using Epitomics® Technology, U.S.Patent No. 5,675,063.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Min Gyu Lee et al.
The Journal of biological chemistry, 278(42), 41047-41058 (2003-08-02)
A common signature of many cancers is a high glucose catabolic rate frequently dependent on the overexpression of Type II hexokinase (HKII), a mitochondrial bound enzyme that also suppresses cell death. As the tumor HKII promoter plays a significant role
CREB: a mediator of long-term memory from mollusks to mammals.
D A Frank et al.
Cell, 79(1), 5-8 (1994-10-07)
J C Yin et al.
Cell, 81(1), 107-115 (1995-04-07)
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB).
G A Gonzalez et al.
Cell, 59(4), 675-680 (1989-11-17)
In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12 cells with forskolin. By contrast, no such induction was observed in the kinase A-deficient PC12 line A126-1B2 (A126). Using F9
R P Kwok et al.
Nature, 370(6486), 223-226 (1994-07-21)
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may
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