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Merck
모든 사진(1)

Key Documents

SAB4200176

Sigma-Aldrich

Anti-JNK antibody, Mouse monoclonal

clone 1C2, purified from hybridoma cell culture

동의어(들):

Anti-JNK-46, Anti-JNK1, Anti-JNK1A2, Anti-JNK21B1/2, Anti-JUN N-terminal kinase, Anti-MAP kinase 8, Anti-MAPK8, Anti-PRKM8, Anti-SAPK1, Anti-stress-activated protein kinase 1

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About This Item

MDL number:
UNSPSC 코드:
12352203
NACRES:
NA.44

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

1C2, monoclonal

분자량

antigen ~43 kDa

종 반응성

mouse, rat, human

농도

~1.0 mg/mL

기술

western blot: 1-2 μg/mL using using whole extracts of mouse NIH-3T3 cells

동형

IgG2a

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−20°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MAPK8(5599)
mouse ... Mapk8(26419)
rat ... Mapk8(116554)

일반 설명

Anti-JNK antibody, Mouse monoclonal, (mouse IgG2a isotype) is derived from the hybridoma 1C2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant protein. JNK1 (c-Jun N-terminal kinase), also known as MAPK8 (mitogen-activated protein kinase 8) is a member of the MAP kinase family. This gene is mapped to human chromosome 10q11.

애플리케이션

Anti-JNK antibody, Mouse monoclonal has been used in immunoblotting and enzyme linked immunosorbent assay (ELISA).

생화학적/생리학적 작용

JNK1 (or MAPK8) is a serine threonine kinase that is a key regulator of cellular apoptosis. During the lack of NFkB stiμLation; persistent activation of JNK1 results in TNF-a induced cell death. However, JNK1 may also function as an apoptotic inhibitor. For instance; JNK1 interacts with WOX1 to inhibit apoptosis. Furthermore, JNK1 phosphorylates Bcl-2 to mediate starvation-induced autophagy, and also activates SIRT1 by phosphorylation during conditions of oxidative stress. JNK1 is activated by UV irradiation and oncoproteins and hence may be implicated in cancer propagation
Monoclonal Anti-JNK antibody is specific for human, mouse and rat JNK1 (43 kDa) and/or JNK2 (55 kDa).
JNK1 is also involved in UV (ultra violet) radiation induced apoptosis, which is thought to be related to cytochrome C-mediated cell death pathway.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

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Neuroscience, 375, 108-118 (2018)
The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss
Kim BJ, et al.
Advances in Experimental Medicine and Biology, Adv(Exp), Med-Med (2018)
JNK Signaling in Apoptosis
Dhanasekaran DN, et al.
Oncogene, 27(48), 6245-6245 (2008)
Trazodone regulates neurotrophic/growth factors, mitogen-activated protein kinases and lactate release in human primary astrocytes
Daniele S, et al.
Journal of Neuroinflammation, 12(1), 1-24 (2015)
Trazodone treatment protects neuronal-like cells from inflammatory insult by inhibiting NF-
Daniele S, et al.
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