SAB4500493

Anti-p38 MAPK antibody produced in rabbit

affinity isolated antibody

• 동의어(들): MAP kinase MXI2, MAP kinase p38, MAPK14, kinase p38-α
• MDL number: MFCD00803556
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: buffered aqueous solution
• 분자량: antigen 41 kDa
• 종 반응성: human, rat, mouse
• 농도: ~1 mg/mL
• 기술: ELISA: 1:10000; western blot: 1:500-1:1000
• NCBI 수납 번호: Q16539
• UniProt 수납 번호: Q16539
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... MAPK14(1432)

설명

일반 설명

Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein.

p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus.

면역원

The antiserum was produced against synthesized peptide derived from human p38 MAPK.

Immunogen Range: 147-196

애플리케이션

Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis.

생화학적/생리학적 작용

p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable