추천 제품
형태
solid
Quality Level
색상
white
solubility
H2O: soluble
methanol: soluble
주관자
Boehringer Ingelheim
저장 온도
2-8°C
SMILES string
Cl[H].Clc1cccc(Cl)c1NC2=NCCN2
InChI
1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
InChI key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
유전자 정보
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.
애플리케이션
Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:
- in ex vivo leptin release assay
- to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
- to study its influence on the sleep of larval zebrafish
- to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation
Clonidine hydrochloride has been used:
- to reduce central noradrenaline levels
- to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
- to attenuate thermal and mechanical pain hypersensitivity in rats
- as a positive control for pertussis toxin (PTX)
생화학적/생리학적 작용
α2-adrenoceptor agonist; I1 imidazoline binding site ligand.
Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.
특징 및 장점
This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 3 Oral
Storage Class Code
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Safety and efficacy of clonidine and clonidine extended-release in the treatment of children and adolescents with attention deficit and hyperactivity disorders
Adolescent health, medicine and therapeutics, 2(2), 105-105 (2011)
INT-005 Development and stability testing of oral clonidine hydrochloride solutions for use in neonatal patients
European Journal of Hospital Pharmacy (2017)
Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective
British journal of anaesthesia, 79(5), 660-661 (1997)
Anaesthesia, 54(2), 146-165 (1999-04-24)
Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have
Evaluation of clonidine hydrochloride (Catapres): a new antihypertensive agent
JAMA : The Journal of the American Medical Association, 233(2), 174-176 (1975)
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