C8417
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
≥98% (TLC), solid, adrenergic neurotoxin
동의어(들):
DSP-4, N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride
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모든 사진(3)
About This Item
실험식(Hill 표기법):
C11H15BrClN · HCl
CAS Number:
Molecular Weight:
313.06
Beilstein:
4020910
MDL number:
UNSPSC 코드:
12352116
PubChem Substance ID:
NACRES:
NA.77
추천 제품
product name
N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, ≥98%, solid
Quality Level
분석
≥98%
형태
solid
색상
white
solubility
H2O: 48 mg/mL
0.1 M NaOH: 7 mg/mL
ethanol: soluble
SMILES string
Cl[H].CCN(CCCl)Cc1ccccc1Br
InChI
1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H
InChI key
NDDRNRRNYOULND-UHFFFAOYSA-N
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생화학적/생리학적 작용
Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.
주의사항
Hygroscopic.
제조 메모
Solutions in ethanol, water or 0.1 N NaOH should be freshly prepared.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
P Szot et al.
Neuroscience, 166(1), 279-291 (2010-01-05)
Degeneration of the noradrenergic neurons in the locus coeruleus (LC) is a major component of Alzheimer's (AD) and Parkinson's disease (PD), but the consequence of noradrenergic neuronal loss has different effects on the surviving neurons in the two disorders. Therefore
Harald Engler et al.
Journal of neuroimmunology, 219(1-2), 75-80 (2009-12-25)
The neurotransmitter noradrenaline (NA) plays a pivotal role in immune regulation. Here we used the selective neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) to investigate the impact of central NA depletion on cytokine production by splenic monocytes/macrophages and T cells. Intraperitoneal administration of DSP-4
Daniel Jardanhazi-Kurutz et al.
Neurochemistry international, 57(4), 375-382 (2010-02-11)
Degeneration of locus ceruleus neurons and subsequent reduction of norepinephrine concentration in locus ceruleus projection areas represent an early pathological indicator of Alzheimer's disease. In order to model the pathology of the human disease and to study the effects of
T Kushikata et al.
British journal of anaesthesia, 107(6), 924-929 (2011-10-04)
Central noradrenergic neurones have a role in alertness, analgesia, and thermoregulation; these neurones are also involved in the mechanism of anaesthesia. Locus coeruleus neurones innervate various central nervous regions including the cerebral cortex and hippocampus, and are responsible for wakefulness
Anna Sadakierska-Chudy et al.
Biochemical pharmacology, 86(6), 800-807 (2013-08-09)
The aim of the present study was to examine the effect of the brain noradrenergic system on the expression of cytochrome P450 in the liver. The experiment was carried out on male Wistar rats. Intracerebroventricular injection of the noradrenergic neurotoxin
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