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Merck
모든 사진(1)

Key Documents

SML0956

Sigma-Aldrich

Dexmedetomidine hydrochloride

≥98% (HPLC)

동의어(들):

(+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride, 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

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About This Item

실험식(Hill 표기법):
C13H16N2 · HCl
CAS Number:
Molecular Weight:
236.74
UNSPSC 코드:
12352200
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

광학 활성

[α]/D +48 to +58°, c = 1 in H2O

저장 조건

desiccated

색상

white to beige

solubility

H2O: 20 mg/mL, clear

저장 온도

2-8°C

InChI

1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

InChI key

VPNGEIHDPSLNMU-MERQFXBCSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

애플리케이션

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.

생화학적/생리학적 작용

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.

특징 및 장점

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

Exclamation markEnvironment

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

표적 기관

Central nervous system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

이미 열람한 고객

Slide 1 of 2

1 of 2

Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes
Ke Peng
Experimental and Therapeutic Medicine (2017)
Heedoo Yoo et al.
European journal of clinical pharmacology, 71(10), 1197-1207 (2015-08-04)
Dexmedetomidine is an α2-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intravenously (IV) and intranasally (IN) administered dexmedetomidine in healthy subjects. Single
3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy
Dengfeng Ding
Experimental and Therapeutic Medicine, 15.4 (2018)
Luis I Cortínez et al.
European journal of clinical pharmacology, 71(12), 1501-1508 (2015-09-27)
This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine. Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Venous blood samples were taken during
Anna K Shoveller et al.
Journal of feline medicine and surgery, 16(12), 957-965 (2014-03-15)
Body condition scoring (BCS) provides a readily available technique that can be used by both veterinary professionals and owners to assess the body condition of cats, and diagnose overweight or underweight conditions. The objective of this study was to evaluate

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