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Merck
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Key Documents

C6594

Sigma-Aldrich

Monoclonal Anti-c-Myc−Cy3 antibody produced in mouse

clone 9E10, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-c-Myc

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

CY3 conjugate

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

9E10, monoclonal

형태

buffered aqueous solution

종 반응성

human

기술

direct immunofluorescence: 1:50 using formalin-fixed, paraffin-embedded human colon carcinoma tissue

UniProt 수납 번호

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... MYC(4609)

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일반 설명

Monoclonal Anti-c-myc (mouse IgG1 isotype) is derived from the 9E10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized BALB/c mouse. The c-Myc gene encodes a polypeptide with a predicted molecular weight of 49 kDa.

면역원

synthetic peptide of the human p62c-Myc protein.

애플리케이션

Monoclonal Anti-c-MycCy3 antibody produced in mouse has been used in:
  • western blotting
  • immunocytochemistry
  • Immunofluorescence

생화학적/생리학적 작용

The encoded protein is involved in cell proliferation, growth and apoptosis. The c-myc gene has been implicated in the development of a number of neoplasms in a variety of avian and mammalian species. The human c-myc protooncogene is the cellular homolog of the avian v-myc gene found in several leukemogenic retroviruses. Increased expression of the cellular oncogene c-myc has been described in a variety of human tumors, occurring by several different mechanisms, including gene amplification and chromosomal translocation.

물리적 형태

Solution in 0.01 M sodium phosphate buffered saline containing 1% bovine serum albumin and 15 mM sodium azide.

법적 정보

Cy3 is a trademark of Cytiva

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


시험 성적서(COA)

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Nir London et al.
Biochemistry, 51(29), 5841-5850 (2012-06-19)
Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their interaction with helical BH3 domains, Bcl-2-like proteins exhibit an intricate spectrum of binding specificities whose underlying basis
Sanjib Dutta et al.
Journal of molecular biology, 398(5), 747-762 (2010-04-07)
Interactions among Bcl-2 family proteins are important for regulating apoptosis. Prosurvival members of the family interact with proapoptotic BH3 (Bcl-2-homology-3)-only members, inhibiting execution of cell death through the mitochondrial pathway. Structurally, this interaction is mediated by binding of the alpha-helical
A highly secreted sulphamidase engineered to cross the blood-brain barrier corrects brain lesions of mice with mucopolysaccharidoses type IIIA
Sorrentino NC, et al.
EMBO Molecular Medicine, 5(5), 675-690 (2013)
Marie Pierron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 36(24), 6525-6537 (2016-06-17)
Diffuse extrasynaptic neurotransmitter receptors constitute an abundant pool of receptors that can be recruited to modulate synaptic strength. Whether the diffuse distribution of receptors in extrasynaptic membranes is a default state or is actively controlled remains essentially unknown. Here we
Human MAMLD1 gene variations seem not sufficient to explain a 46, XY DSD phenotype
Camats N, et al.
PLoS ONE, 10(11), e0142831-e0142831 (2015)

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