추천 제품
형태
powder
색상
white
주관자
Johnson & Johnson
SMILES string
C1CN(CCN1C\C=C\c2ccccc2)C(c3ccccc3)c4ccccc4
InChI
1S/C26H28N2/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25/h1-17,26H,18-22H2/b13-10+
InChI key
DERZBLKQOCDDDZ-JLHYYAGUSA-N
유전자 정보
human ... CACNA1A(773) , CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , DRD2(1813) , HRH1(3269)
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Cinnarizine is a piperazine derivative, which is extracted from wood reed roots. It exhibits antihistaminic and calcium antagonist property. Cinnarizine is used to treat vertigo, unsteadiness and cognitive disorders. Cinnarizine has anticholinergic, antiserotonergic and antidopaminergic effects. It enhances cerebral blood flow. Cinnarizine blocks the contraction of smooth muscles cells and also acts as a skin whitening agent.
애플리케이션
Cinnarizine has been used to block pressure-dependent changes in potassium currents in acutely isolated inner hair cells of the guinea-pig cochlea using whole-cell voltage-clamp techniques. It has also been used in the in vivo and in vitro studies, to analyze the impact of drug load and physical form of cinnarizine in self-nanoemulsifying drug delivery systems (SNEDDS) on absorption in rats.
Cinnarizine has been used:
- to study its role in self-nano emulsifying drug delivery systems (SNEDDS)(8)(10)
- to test Ca2+ signaling is pivotal for cancer-associated fibroblasts (CAFs) retraction(9)
- as a model drug to develop a high-throughput in vitro intestinal lipolysis (HTP) model(11)
생화학적/생리학적 작용
Ca2+ channel blocker; central and peripheral vasodilator.
Cinnarizine is a piperazine and a specific anti-vertigo agent. It is used to treat and prevent vertigo and motion sickness. In addition, cinnarizine is also used as an anti-histamine agent. Chronic use of this drug leads to side effects such as extrapyramidal reactions (Parkinson, tremor and akathisia) and depression.
특징 및 장점
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
이미 열람한 고객
Influence of drug load and physical form of cinnarizine in new SNEDDS dosing regimens: in vivo and in vitro evaluations
Siqueira SDVS, et al.
The AAPS Journal, 19(2), 587-594 (2017)
Cinnarizine in the treatment of peripheral vascular disease: mechanisms related to its clinical action
Emanuel MB and Will JA
Proceedings of the Royal Society of Medicine, 70(8), 7-12 (1977)
The effect of pressure on potassium currents in the inner hair cells isolated from guinea-pig cochlea
Kimitsuki T
Acta Neurobiologiae Experimentalis, 73, 521-528 (2013)
Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomach
Raghuvanshi S and Pathak K
Journal of Drug Delivery, 201 (2014)
Anne T Larsen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(1-2), 339-350 (2012-11-28)
The in vivo performance of self-nanoemulsifying drug delivery systems (SNEDDSs) with different in vitro physicochemical properties were determined with the purpose of elucidating the parameters determining the in vivo performance of SNEDDSs. The in vitro characterisation included the use of
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