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Merck
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주요 문서

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T7883

Sigma-Aldrich

Trimethoprim

≥98.5%

동의어(들):

2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C14H18N4O3
CAS Number:
738-70-5
Molecular Weight:
290.32
Beilstein:
625127
EC Number:
212-006-2
MDL number:
MFCD00036761
UNSPSC 코드:
51285203
PubChem Substance ID:
24278201
NACRES:
NA.85

Quality Level

200

분석

≥98.5%

양식

powder

저장 조건

(Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)

색상

white to light yellow

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

동작 모드

DNA synthesis | interferes
enzyme | inhibits

저장 온도

2-8°C

SMILES string

COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18)

InChI key

IEDVJHCEMCRBQM-UHFFFAOYSA-N

유전자 정보

human ... DHFRP1(573971) , KCNH1(3756)
rat ... Dhfr(24312)

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관련 카테고리

일반 설명

Chemical structure: pyrimidine

애플리케이션

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.
Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

생화학적/생리학적 작용

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

포장

5G,25G,100G

기타 정보

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

픽토그램

Health hazardExclamation mark
GHS08,GHS07

신호어

Warning

유해 및 위험 성명서

H302,H361d

Hazard Classifications

Acute Tox. 4 Oral - Repr. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
066M4057V
039M4001V
019M4019V
019M4102V
098M4075V

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