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T0667

Sigma-Aldrich

Trimethoprim lactate salt

≥98%

동의어(들):

5-(3,4,5-Trimethoxybenzyl)pyrimidine-2,4-diamine 2-hydroxypropanoate, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine lactate salt

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C14H18N4O3 · C3H6O3
CAS Number:
23256-42-0
Molecular Weight:
380.40
EC Number:
245-533-1
MDL number:
MFCD00171722
UNSPSC 코드:
51285203
PubChem Substance ID:
329826610
NACRES:
NA.85

Quality Level

200

분석

≥98%

형태

powder

저장 조건

(Keep container tightly closed in a dry and well-ventilated place.)

색상

white

solubility

H2O: soluble 20 mg/mL

항생제 활성 스펙트럼

Gram-negative bacteria
Gram-positive bacteria
mycobacteria

동작 모드

DNA synthesis | interferes
enzyme | inhibits

저장 온도

2-8°C

SMILES string

CC(O)C(O)=O.COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC

InChI

1S/C14H18N4O3.C3H6O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15;1-2(4)3(5)6/h5-7H,4H2,1-3H3,(H4,15,16,17,18);2,4H,1H3,(H,5,6)

InChI key

IIZVTUWSIKTFKO-UHFFFAOYSA-N

관련 카테고리

일반 설명

Chemical structure: pyrimidine

애플리케이션

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used clinically to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections. Trimethoprim lactate salt is used as a selection agent.

생화학적/생리학적 작용

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to prokaryote-specific dihydrofolate reductase (DHFR) and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

픽토그램

Skull and crossbonesHealth hazard
GHS06,GHS08

신호어

Danger

유해 및 위험 성명서

H301,H361d

Hazard Classifications

Acute Tox. 3 Oral - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

시험 성적서(COA)

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