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Merck
모든 사진(2)

Key Documents

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C117

Sigma-Aldrich

5-Carboxamidotryptamine maleate salt

powder, ≥98% (HPLC)

동의어(들):

5-CT, AH-21467

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모든 사진(2)

About This Item

실험식(Hill 표기법):
C11H13N3O · C4H4O4
CAS Number:
74885-72-6
Molecular Weight:
319.31
MDL number:
MFCD00069224
UNSPSC 코드:
12352116
PubChem Substance ID:
24278086
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

색상

white to off-white

solubility

H2O: 10 mg/mL

저장 온도

−20°C

SMILES string

OC(=O)\C=C/C(O)=O.NCCc1c[nH]c2ccc(cc12)C(N)=O

InChI

1S/C11H13N3O.C4H4O4/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10;5-3(6)1-2-4(7)8/h1-2,5-6,14H,3-4,12H2,(H2,13,15);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

PZQZSWAOVAMBQM-BTJKTKAUSA-N

유전자 정보

human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR2A(3356) , HTR2C(3358) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363)
rat ... Htr7(65032)

생화학적/생리학적 작용

Agonist at 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 serotonin receptors.

호환 제품

제품 번호
설명
가격

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

시험 성적서(COA)

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Andrea Hembre Ulsund et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33(3), 3870-3886 (2018-12-07)
According to early models of GPCR signaling, G proteins only interact with activated receptors. However, some GPCRs were shown to assemble with G proteins before receptor activation, in accordance with more recent models. Previously, we found that the 5-HT7 receptor
Omkar L Patkar et al.
Addiction biology, 24(4), 652-663 (2018-07-20)
Repeated cycles of binge-like alcohol consumption and abstinence change the activity of several neurotransmitter systems. Some of these changes are consolidated following prolonged alcohol use and are thought to play an important role in the development of dependence. We have
Kirsten E Hoff et al.
PloS one, 13(8), e0203198-e0203198 (2018-08-30)
Mutations in mitochondrial DNA (mtDNA) have been linked to a variety of metabolic, neurological and muscular diseases which can present at any time throughout life. MtDNA is replicated by DNA polymerase gamma (Pol γ), twinkle helicase and mitochondrial single-stranded binding
Ayako Moritomo et al.
Bioorganic & medicinal chemistry, 22(15), 4323-4337 (2014-06-12)
We previously reported that the novel dual 5-HT₂B and 5-HT7 receptor antagonist N-(9-hydroxy-9H-fluorene-2-carbonyl)guanidine (4) exerted a suppressing effect on 5-HT-induced dural protein extravasation in guinea pigs. To develop a synthetic strategy, we performed docking studies of lead compound 4 bound
W L Bacon et al.
The Journal of pharmacology and experimental therapeutics, 294(2), 672-679 (2000-07-20)
The 5-hydroxytryptamine(7) (5-HT(7)) receptor was originally defined by molecular biology techniques. The 5-HT(7) receptor protein and mRNA are found in brain areas, such as the CA3 subfield of the hippocampus, that are involved in various neuropsychiatric disease states. No functional
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